This Pathogenic game wiki brings together officially documented Organelles, all 41 Steam achievements, the seven-Pathogen roster, six main body regions, co-op setup and dated patch changes. Source links make it easy to separate confirmed information from launch-week rumors.
Game overview
Pathogenic is a 2D roguelike twin-stick shooter developed by Aberrant Labs and published by Slug Disco. You play as a lone parasite inside a procedurally generated human body, fighting immune cells while changing the shape and behavior of your organism. The full game launched on July 16, 2026 for Windows, macOS and Linux.
A run is built around collecting Organelles and grafting them onto your Pathogen. Weapons, movement parts, power sources and support pieces can be connected so one effect changes or triggers another. The useful question is not simply which reward looks strongest, but what role the current organism is missing and whether the new piece actually connects to the rest of the build.
Progress also continues between runs through permanent Plasmid upgrades. The official 1.0 release record confirms seven playable Pathogens, six main body regions and more than 120 Organelles and Mutations combined; Steam lists 41 achievements. This wiki lists only records that can be described from traceable evidence.
Collect attack, movement, power and support Organelles. Placement and connections determine what the organism can do during the current run.
Connection arrows and expanded tooltips show which pieces interact. Use those signals before assuming that nearby Organelles create a synergy.
Spend Plasmid fragments on permanent progression for the Pathogen you are using. Each roster member has a separate upgrade tree.
Start with the player question
Reach the hidden Brain, make safer first-run decisions, check the complete roster, set up co-op or confirm what transferred from the demo.
Learn how to reach the Brain in Pathogenic step by step: enter the fixed code, collect four hidden shapes, solve the Heart puzzle and unlock the secret ending.
To reach the Brain in Pathogenic, clear the Heart once and record the fixed code: Right, Up, Down, Up, Right, Left. On the next run, unlock and power the Skin tracker, collect four regional shapes, then use their run-specific arrow mapping after the Heart to open the Brain route and unlock the secret ending.How to beat the Pathogenic Brain boss, Naegleria Fowleri: what the fight demands, the organelle roles that matter, a build that clears it, and the builds that fail.
The Pathogenic Brain is a boss rush of returning bosses, ending in the final boss Naegleria Fowleri. The fight demands sustained single-target damage, survival against its dash, ring, lightning, and distortion-field traps, and damage that keeps going when your actives cool down. One build has cleared it on video: Fungal Spore with minions (Nidublast, Apex Nidus), a Pristine Mitochondrion for Overcharge, an invulnerability active, and freeze. Killing it unlocks the true ending. This page covers what to bring, one build that clears it, and the builds that fail.Learn how Overcharge works in Pathogenic, whether multiple Mitochondria stack, how Overcharge Strength changes effects and how to test real damage.
Overcharge in Pathogenic is power generated by Mitochondria and passed through valid chain connections to compatible Organelles. Developer replies confirm that Overcharge stacks, and that extra Overcharge or Overcharge Strength can make an effect charge faster. A second Mitochondrion does not guarantee a simple 2x final-damage result: read the receiving effect, verify the connection arrows and compare Last Room Damage in the expanded tooltip.How Burn works in Pathogenic: the Organelles that apply it, how burn scales with rarity, what to keep or reroll, and why two builds deal different damage.
Burn in Pathogenic is a damage-over-time status. Two Organelles apply it directly: Pyroflagellum leaves a burning trail when you dodge, and Oxidator applies burn-on-hit — doubled at Epic+ rarity. Players also reach large burn totals with high-frequency projectile builds and melee builds, and a fire option called Pyrogenesis can spread burn when a burning enemy dies. Burn grows fastest when it is applied often and the build is correctly chained to Overcharge, so a burn build is a chain, not a pile. The “5000 burn” figure is one player’s result, not a target the game sets; the “Reach X Burn” unlocks are real and depend on the right parts showing up.Pathogenic beginner guide: core controls, reading the organelle editor and chain arrows, the five organelle roles, a stable first build, organs, the shop, and seeds.
Pathogenic is a 2D roguelike where you build a pathogen from Organelles and fight through six organs. For your first run: learn the four core controls (move with WASD, aim and shoot with the mouse, dodge with Space, open the editor with Tab and the map with M); read the editor before confirming a part, so the chain arrows actually reach your weapons; build one stable main attack first, then add Mitochondria for power and something for movement or defense; and spend Plasmid fragments between runs on the shortfall that killed you. The deeper guides linked at the bottom cover Overcharge, the full Organelle list, the pathogen roster, and the secret Brain route.Meet all seven Pathogens, compare their playstyles and trade-offs, and choose the right fit for solo runs, custom shapes or two-player co-op.
Pathogenic has seven playable Pathogens. Bacterium is a simple place to learn the basics; Helminth is commonly built around melee reach; Amoeba and Nanobot focus on shape building; Fungal Spore uses fixed special slots; Diatom is the two-player option; and lil collector changes movement with wall-clinging. Your best choice depends on the controls and build style you enjoy.Pathogenic co-op explained: local two-player via the Diatom is supported, there is no native online mode, and a remote friend joins through Steam Remote Play Together.
Pathogenic supports local two-player co-op but has no native online multiplayer. The Diatom is the two-player Pathogen — each player controls one half. A remote friend can still join your local session through Steam Remote Play Together, which streams the host’s game to them. This page covers the three options, the invite flow, how to split controller/keyboard/mouse between two players, and the most common setup failures.What officially transferred from the Pathogenic demo to the full game, and what the developer did not promise to migrate.
The developer announced that accumulated Plasmids from the demo would transfer to the full game at launch. The announcement did not promise a complete save, unlock or run-state migration.Start with 20 officially documented Organelles, the complete seven-Pathogen roster, all 41 Steam achievements and the six main body regions. Brain is secret content and is listed separately from the main progression path.
Solo and co-op
Pathogenic supports local co-op but does not include native online multiplayer. A remote second player can join the host’s local session through Steam Remote Play Together. Diatom is the two-player Pathogen, with each player controlling one half. Connection quality and input setup depend on the host because the remote session is streamed.
Open the co-op setup guideLatest official changes
The July 18 official change summary covers several launch hotfixes: about 20 additional Stomach and Liver rooms, new text-size and frame-rate settings, balance changes, deeper save protection and a fix for players becoming stuck in demo mode after the Liver.
Read the July 18 launch hotfixesSource policy
Each guide links the official store page, developer announcement, Steam record or Steam help page used for its answer. Update dates show when the page changed, while uncertain unlock steps and exact values are left out instead of being presented as fact.
Quick facts